Superoxide Dismutases in Biology and Medicine: Essentials and Recent Advances

  • Ben D. Little American Institute of Innovative Medical Sciences and Technologies, P.O. Box 37504, Raleigh, NC 27626, USA
  • Robert Z. Hopkins American Institute of Innovative Medical Sciences and Technologies, P.O. Box 37504, Raleigh, NC 27626, USA
Keywords: Epigenetics; Gene regulation; Peroxidase; Redox signaling; Superoxide dismutase; Superoxide toxicity; Tumorigenesis

Abstract

Superoxide dismutases (SODs) are a family of enzymes catalyzing the dismutation of superoxide to hydrogen peroxide and molecular oxygen. SODs are among the most extensively studied antioxidant enzymes in mammalian systems. This article provides an overview on the basic biochemistry and molecular regulation of SODs and summarizes recent cutting-edge research findings on their biological functions as well as implications in health and disease.

Published
2020-01-01
How to Cite
Little, B. D., & Hopkins, R. Z. (2020). Superoxide Dismutases in Biology and Medicine: Essentials and Recent Advances. Reactive Oxygen Species, 9(25), 13–21. Retrieved from https://www.aimsci.com/ros/index.php/ros/article/view/253
Section
Review Articles