GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis

  • Hong Zhu Department of Physiology and Pathophysiology, Campbell University Medical School, Buies Creek, NC 27506, USA
  • Arben Santo Department of Pathology, EVCOM, Virginia Tech CRC, Blacksburg, VA 24060, USA
  • Zhenquan Jia Department of Biology, University of North Carolina College of Arts and Sciences, Greensboro, NC 27412, USA; Department of Pharmacology, Campbell University Medical School, Buies Creek, NC 27506, USA; Department of Pharmaceutical Sciences, Campbell University College of Pharmacy and Health Sciences, Buies Creek, NC 27506, USA
  • Y. Robert Li Department of Biology, University of North Carolina College of Arts and Sciences, Greensboro, NC 27412, USA; Department of Pharmacology, Campbell University Medical School, Buies Creek, NC 27506, USA; Department of Pharmaceutical Sciences, Campbell University College of Pharmacy and Health Sciences, Buies Creek, NC 27506, USA; Virginia Tech‒Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
Keywords: Bacterial infection; Ferroptosis; GPx4; Lipid peroxidation; Pyroptosis; Sepsis

Abstract

While it is well known that bacterial infection is the predominant cause of sepsis, the molecular pathophysiology of this clinical syndrome remains ill-defined. In this Research Highlights article, we discuss the recent research findings regarding a protective role for glutathione peroxidase-4 (GPx4) in bacterial infection and polymicrobial sepsis via modulating ferroptosis and pyroptosis, two novel modes of regulated cell death. It is suggested that GPx4, being a requisite gateway to both ferroptosis and pyroptosis, may serve as a critical molecular target for developing effective drugs for controlling infection and sepsis.

 

Published
2019-05-01
How to Cite
Zhu, H., Santo, A., Jia, Z., & Li, Y. R. (2019). GPx4 in Bacterial Infection and Polymicrobial Sepsis: Involvement of Ferroptosis and Pyroptosis. Reactive Oxygen Species, 7(21), 154–160. Retrieved from https://www.aimsci.com/ros/index.php/ros/article/view/217
Section
Research Highlights