A Review on the Antioxidative and Prooxidative Properties of Luteolin

  • Haixia Xu Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, and Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 210032, China
  • Becky S. Linn School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
  • Yingmei Zhang Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, and Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 210032, China; School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
  • Jun Ren Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, and Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 210032, China; School of Pharmacy, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA
Keywords: Antioxidative activity; Luteolin; Oxidative stress; Reactive oxygen species; Redox balance

Abstract

Luteolin is a natural flavonoid compound mainly present as glycosides in vegetables, fruits, and herbs including carrot, cabbage, artichoke, tea, celery, and apple. Evidence has revealed that luteolin possesses profound biological properties such as antimutagenic, antitumorigenic, antioxidative, immunomodulatory, anticarcinogenic, antibacterial, antiapoptotic, and anti-inflammatory capacities. In particular, luteolin helps preserve the oxidation and antioxidation balance, the disruption of which plays a crucial role in the pathophysiologic processes of various diseases including cardiovascular disorders, cancers, and neurodegenerative diseases. This mini-review briefly summarizes the established beneficial effect of luteolin with regard to the maintenance of balance between pro- and anti-oxidation. We will provide an overview of luteolin and its therapeutic application in cardiovascular diseases, cancers, and neurodegenerative diseases.

Published
2019-05-01
How to Cite
Xu, H., Linn, B. S., Zhang, Y., & Ren, J. (2019). A Review on the Antioxidative and Prooxidative Properties of Luteolin. Reactive Oxygen Species, 7(21), 136–147. Retrieved from https://www.aimsci.com/ros/index.php/ros/article/view/198
Section
Review Articles