Mind-Body Interventions Significantly Decrease Oxidative DNA Damage in Sperm Genome: Clinical Implications

  • Vidhu Dhawan Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
  • Manoj Kumar Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
  • Priyanka Chaurasia Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
  • Rima Dada Laboratory of Molecular Reproduction and Genetics, Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India
Keywords: Embryogenesis; Gene expression; Infertility; Meditation; Mind-body interactions; Oxidative DNA damage; Oxidative stress; Yoga

Abstract

Mind-body interventions (MBIs) have been broadly categorized into a group of interventions which facilitate mind’s capacity to affect the functions of the body. There is a growing body of evidence suggesting the adoption of MBIs like yoga, meditation, Tai Chi, and Qigong as an adjunct in the management of various complex lifestyle-related disorders. This review summarizes the importance of simple yoga- and meditation-based lifestyle intervention as a critical component of male infertility therapy. Defective chromatin integrity is one of the hallmarks of male factor infertility. Regular practice of yoga and meditation affects and targets the whole body, decreases free radical levels, and causes collateral increase in levels of antioxidants, not only resulting in improvement in standard sperm parameters, but also becoming ideal in treating oxidative stress oxidative DNA damage and modulating levels of sperm transcripts through affecting the sperm methylome. This may aid in reversing testicular aging and improving the overall health and quality of life of male infertility patients and of the next generation.

Published
2018-10-30
How to Cite
Dhawan, V., Kumar, M., Chaurasia, P., & Dada, R. (2018). Mind-Body Interventions Significantly Decrease Oxidative DNA Damage in Sperm Genome: Clinical Implications. Reactive Oxygen Species, 7(19). Retrieved from https://www.aimsci.com/ros/index.php/ros/article/view/165
Section
Review Articles