MnSOD/SOD2 in Cancer: The Story of a Double Agent
Manganese-dependent superoxide dismutase (MnSOD/SOD2) is one of the major antioxidant enzymes which scavenges the superoxide produced in the mitochondria, the main source of free radicals in non-pathological conditions. This first barrier is important to prevent early stages of cancer development. However, once the tumor is established, upregulation of MnSOD without a concomitant increase of scavengers of hydrogen peroxide (H2O2) plays a much complex role. It contributes to proliferation, angiogenesis and invasion, affecting glycolytic metabolism and preventing the mitochondria from inducing apoptosis favoring therapy resistance. The increase of H2O2 mediated by MnSODis able to induce phenotypical changes in several tumor types, such as epithelia-mesenchymal transition increasing the motility of tumor cells, neuroendocrine differentiation and senescent secretory phenotypes which feed tumor progression by producing cytokines and growth factors.
Submission of an original manuscript to the Journal will be taken to mean that it represents original work not previously published; that it is not being considered elsewhere for publication; that the author(s) agrees to assign copyright to the Journal upon acceptance for publication in the Journal, and if accepted for publication, it will be published in the digital format (PDF) and/or in print and it will not be published elsewhere in the same form, for commercial purposes, in any language, without the consent of the Publisher.